Russian Academy of Medical Science, Moscow Endocrinology Science Center (Director I.I. Dedov) English (professional translation .pdf)
The influence of arbidol on lipid peroxidation in diabetic patients
N.I. Fadeeva, M.I. Balabolkin, G.G. Mamaeva, R.G. Glushkov, A.P. Knyazeva
There has been increased interest in a highly effective antiviral preparation (arbidol 1
methyl 2 phenylmethyl 3 carboethoxyl 4 dimetilaminomethyl 5 oxy 6
bromo-hydrochloride monohydrate), which also has immuno-modulating properties [30].
Arbidols antioxidant properties [7] can act as a sort of trap against the peroxidation
mechanism [24].
The goal of the present study was to examine the influence of arbidol on LPO, and the
effects of antioxidant defense for type II diabetes patients.
Original Russian Document
Lipid Peroxidation in Arbidol No. 4 23.03.99. English (professional translation .html) (or .pdf)
ANTIOXIDANT PROPERTIES OF ARBIDOL AND ITS STRUCTURAL ANALOGUES
O.V. VASILJEVA, O.B. LYUBITSKY1, T.A. GUSKOVA2, R.G. GLUSHKOV2, O.S. MEDVEDEV, YU.A. VLADIMIROV1
MV Lomonosov
The effect of arbidol and its structural analogues on the process of lipid peroxidation in phospholipid
liposomes induced by Fe2+ has been investigated. It was shown that the antioxidant efficacy of arbidol and its derivatives is lower
than that of alfa-tocopherol by two or three times. It was suggested that the mechanism antioxidant action of the arbidol and its
structural analogues consists of scavenging of lipid radicals rather than chelating of Fe2+.
Original Russian Document